Protein domain analysis in the era of complete genomes

FEBS Letters

Letunic, Ivica¹  Bork, Peer¹  Copley, Richard R.¹  Doerks, Tobias¹ 

[1] EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany

关键词: Protein domains;    Genome analysis;    Evolution;    Sequence analysis;   

DOI  :  10.1016/S0014-5793(01)03289-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.

【 授权许可】

Unknown