The paxillin LD motifs

FEBS Letters

Tumbarello, David A¹  Turner, Christopher E¹  Brown, Michael C¹ 

[1] Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA

关键词: Actin cytoskeleton;    Cell adhesion;    Focal adhesion;    Integrin signaling;   

DOI  :  10.1016/S0014-5793(01)03244-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adapter/scaffold proteins, through their multidomain structure, perform a fundamental role in facilitating signal transduction within cells. Paxillin is a focal adhesion adapter protein implicated in growth factor- as well as integrin-mediated signaling pathways. The amino-terminus of paxillin contains five leucine-rich sequences termed LD motifs. These paxillin LD motifs are highly conserved between species as well as within the paxillin superfamily. They mediate interactions with several structural and regulatory proteins important for coordinating changes in the actin cytoskeleton associated with cell motility and cell adhesion as well as in the regulation of gene expression.

【 授权许可】

Unknown