Signaling to the Rho GTPases: networking with the DH domain

FEBS Letters

Cerione, Richard A¹  Hoffman, Gregory R¹ 

[1] Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA

关键词: Dbl;    GEF;    DH;    Guanine nucleotide exchange factor;   

DOI  :  10.1016/S0014-5793(01)03310-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine nucleotide exchange on the Rho family GTPase Cdc42. Since the initial biochemical characterization of the DH domain, this conserved motif has been identified in a large family of proteins. In each case, a pleckstrin homology (PH) domain immediately follows the DH domain and this tandem DH–PH module is the signature motif of the Dbl family of guanine nucleotide exchange factors (GEFs). Recent structural studies have provided significant insight into the molecular basis of guanine nucleotide exchange by Dbl family GEFs, opening the door for understanding the specificity of the DH/GTPase interaction as well as providing a starting point for understanding how the exchange activity of these proteins is modulated to achieve specific biological outcomes in the cell.

【 授权许可】

Unknown