Molecular simulations of the large conductance mechanosensitive (MscL) channel under mechanical loading

FEBS Letters

Mylvaganam, Kausala¹  Bilston, Lynne E¹ 

[1]School of Aerospace Mechanical and Mechatronic Engineering, Building J07, University of Sydney, NSW 2006, Sydney, Australia

关键词: Molecular dynamics;    Mechanotransduction;    Ion channel;    Membrane tension;    MscL;    large conductance mechanosensitive;   

DOI  :  10.1016/S0014-5793(02)02254-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The MscL channel is a mechanosensitive channel which is gated by membrane stress or tension. Here, we describe a series of simulations which apply simulated mechanical stress to a molecular model of the MscL channel using two methods – direct force application to the transmembrane segments, and anisotropic pressure coupling. In the latter simulations, pressures less than that equivalent to a bilayer tension of 12 dyn/cm did not cause the channel to open, while pressures in excess of this value resulted in the channel opening. These results are in approximate agreement with experimental findings.

【 授权许可】

Unknown