Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans

FEBS Letters

Hekimi, Siegfried²  Kano, Kenji¹  Miyadera, Hiroko³  Ishii, Naoaki⁴  Kita, Kiyoshi³  Miyoshi, Hideto¹ 

[1] Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan;Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montréal, QC, Canada H3A 1B1;Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan

关键词: Ubiquinone;    Demethoxy ubiquinone;    clk-1;    Ageing;    Reactive oxygen species;    Longevity;    ROS;    reactive oxygen species;    UQ;    ubiquinone (2;    3-dimethoxy-5-methyl-6-polyprenyl-1;    4-benzoquinone);    DMQ;    demethoxy ubiquinone (2-methoxy-5-methyl-6-polyprenyl-1;    4-benzoquinone);    complex I;    NADH-ubiquinone reductase;    complex II;    succinate-ubiquinone reductase;    Qred;    reduced quinone;    complex III;    ubiquinol-cytochrome c reductase;    Qox;    oxidized quinone;    3-hydroxy UQ2;    2-methoxy-3-hydroxy-5-methyl-6-polyprenyl-1;    4-benzoquinone;    Qsem;    semiubiquinone radical;    AOX;    alternative oxidase;   

DOI  :  10.1016/S0014-5793(02)02282-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ubiquinone (UQ) (coenzyme Q) is a lipophilic redox-active molecule that functions as an electron carrier in the mitochondrial electron transport chain. Electron transfer via UQ involves the formation of semiubiquinone radicals, which causes the generation of superoxide radicals upon reaction with oxygen. In the reduced form, UQ functions as a lipid-soluble antioxidant, and protects cells from lipid peroxidation. Thus, UQ is also important as a lipophilic regulator of oxidative stress. Recently, a study on long-lived clk-1 mutants of Caenorhabditis elegans demonstrated that biosynthesis of UQ is dramatically altered in mutant mitochondria. Demethoxy ubiquinone (DMQ), that accumulates in clk-1 mutants in place of UQ, may contribute to the extension of life span. Here we elucidate the possible mechanisms of life span extension in clk-1 mutants, with particular emphasis on the electrochemical property of DMQ. Recent findings on the biochemical function of CLK-1 are also discussed.

【 授权许可】

Unknown