Expression and regulation of the nuclear receptor RORα in human vascular cells

FEBS Letters

Rodriguez, Marianne³  Tedgui, Alain⁴  Mariani, Jean²  Merval, Régine⁴  Besnard, Sandrine⁴  Boutin, Jean A³  Heymes, Christophe¹  Galizzi, Jean-Pierre³ 

[1] INSERM U127, Hôpital Lariboisière, 75475 Paris, France;Pharmacologie Moléculaires et Cellulaire, Institut de Recherches SERVIÉR, 78290 Croissy, France;CNRS URA 1199, Université Pierre et Marie Curie, 75252 Paris, France;INSERM U541, Hôpital Lariboisière, 41 Bd de la Chapelle, 75475 Paris Cedex 10, France

关键词: Nuclear receptor;    Smooth muscle cell;    Endothelial cell;    Cytokine;    Hypoxia;   

DOI  :  10.1016/S0014-5793(01)03275-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Retinoic acid receptor-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily. Using RT-PCR, RORα mRNA was identified in human aortic smooth muscle cells (hASMC), endothelial cells (EC), as well as in human mammary arteries and atherosclerotic plaques. We found a predominant expression of RORα1 in hASMC, and RORα4 in EC. RORα2 and RORα3 were not detected. In arteries, RORα4 was predominant compared with RORα1. In atherosclerotic plaques, RORα expression was significantly decreased. In hASMC stimulated with cytokines, RORα expression was increased by 2.5-fold. RORα mRNA was also significantly increased (∼2-fold) in hASMC and EC cultured under hypoxia.

【 授权许可】

Unknown