Distribution of GyrA intein in non‐tuberculous mycobacteria and genomic heterogeneity of Mycobacterium gastri

FEBS Letters

Mamadou, Daffé¹  Isabelle, Saves¹  Jean-Michel, Masson¹ 

[1] Institut de Pharmacologie et Biologie Structurale, UMR 5089 CNRS/UPS, 205 Route de Narbonne, F-31077 Toulouse Cedex, France

关键词: Intein;    Protein splicing;    Mycobacteria;    RecA;    GyrA;    Pps1;    Mfl;    Mycobacterium flavescens;    Mga;    Mycobacterium gastri;    Mgo;    Mycobacterium gordonae;    Mka;    Mycobacterium kansasii;    Mle;    Mycobacterium leprae;    Mma;    Mycobacterium malmoense;    Mtu;    Mycobacterium tuberculosis;    Mxe;    Mycobacterium xenopi;   

DOI  :  10.1016/S0014-5793(01)03037-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To gain further insights into the understanding of the intein invasion process in mycobacteria, intein sequences in the gyrA gene of 42 mycobacterial strains were searched and a new gyrA intein was found in Mycobacterium gastri (Mga). This 1260 bp intein, named MgaGyrA, inserted at the GyrA-a site, is highly homologous to the members of the Mycobacterium leprae GyrA allelic family. As the recA intein, MgaGyrA was detected in only one out of six Mga strains examined, while the pps1 intein was a constant character of Mga. This data supports the genomic heterogeneity of Mga towards intein invasion, a finding that may have phylogenetic implications.

【 授权许可】

Unknown