Inteins invading mycobacterial RecA proteins

FEBS Letters

Lanéelle, Marie-Antoinette¹  Masson, Jean-Michel¹  Saves, Isabelle¹  Daffé, Mamadou¹ 

[1] Institut de Pharmacologie et Biologie Structurale (UMR5089), C.N.R.S./Université Paul Sabatier Toulouse III, 205 Route de Narbonne, F-31077 Toulouse Cedex, France

关键词: Intein;    Protein splicing;    Mycobacterium;    RecA;    Mch;    Mycobacterium chitae;    Mfa;    M. fallax;    Mfl;    M. flavescens;    Mga;    M. gastri;    Mle;    M. leprae;    Msh;    M. shimodei;    Msmeg;    M. smegmatis;    Mth;    M. thermoresistibile;    Mtu;    M. tuberculosis;   

DOI  :  10.1016/S0014-5793(00)01944-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Five new inteins were discovered in a survey of 39 mycobacterial strains that was undertaken to clarify the role of RecA inteins in mycobacteria. They are all inserted at the RecA-b site of the recA gene of Mycobacterium chitae, M. fallax, M. gastri, M. shimodei and M. thermoresistibile and belong to the MleRecA allelic family. Sequence analysis showed that although only M. tuberculosis harbours an intein at the RecA-a site the sequence of the RecA-b site is well conserved between species. Furthermore, the presence of inteins does not correlate with specific characteristics of the species such as pathogenicity or growth rate.

【 授权许可】

Unknown