A novel dicyclodextrinyl ditelluride compound with antioxidant activity

FEBS Letters

Mu, Ying²  Ren, Xiaojun³  Shen, Jiacong³  Luo, Guimin²  Liu, Junqiu³  Zhang, Kun²  Zheng, Jian¹  Xue, Yan² 

[1] Department of Chemistry, Jilin University, Changchun 130023, PR China;Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130023, PR China;Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, 125 Jiefang Road, Changchun 130023, PR China

关键词: Antioxidant activity;    Artificial enzyme;    Cyclodextrin;    Glutathione peroxidase;    Tellurium;    ROS;    reactive oxygen species;    GPX;    glutathione peroxidase;    Ebselen;    2-phenyl-1;    2-benziososelenazol-3(2H)-one;    2-TeCD;    dicyclodextrinyl ditelluride;    t-BuOOH;    tert-butylhydroperoxide;    CuOOH;    cumene hydroperoxide;    GSH;    glutathione;    β-CD;    β-cyclodextrin;    NADPH;    β-nicotinamide adenine dinucleotide phosphate;    TBARS;    thiobarbituric acid reactive substances;   

DOI  :  10.1016/S0014-5793(01)03011-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Reactive oxygen species (ROS) primarily arise from products of normal metabolic activities and are thought to be the etiology of many diseases. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was designed to be a functional mimic of the glutathione peroxidase that normally removes ROS. 2-TeCD exhibited highly catalytic efficiency and good water solubility. Antioxidant activity was studied by using ferrous sulfate/ascorbate-induced mitochondria damage model system. 2-TeCD protected the mitochondria against oxidative damage in a dose-dependent manner and exhibited also great antioxidant ability in comparison with 2-phenyl-1,2-benziososelenazol-3(2H)-one. The mimic may result in better clinical therapies for the treatment of ROS-mediated diseases.

【 授权许可】

Unknown