FEBS Letters | |
Dynamic flexibility in the Escherichia coli genome | |
Tsai, Lu1  Sun, Zhirong1  | |
[1] Department of Biological Science and Technology, Tsinghua University, Beijing 100084, PR China | |
关键词: Base-pair step interaction; DNA flexibility; Statistical mechanical model; Whole-genome analysis; NDB; nucleic acid database; CDS; coding region; | |
DOI : 10.1016/S0014-5793(01)02978-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Empirical rules based on tetranucleotide parameters were presented to predict the structural parameters twist (Ω), roll (ρ), tilt (τ) and slide (Dy ). A statistical mechanical model was used to analyze the flexibility of the Escherichia coli genome. The replication terminus region displayed a low level of flexibility. A strong correlation can be seen between G+C content and flexibility. Average flexibilities in the coding regions were found to be significantly larger than those in non-coding regions. The flexible characteristics in the 5′-neighborhood of the coding regions and in three class sigma promoter sequences in the E. coli genome were also analyzed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020311084ZK.pdf | 215KB | download |