HIV‐1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

FEBS Letters

Maga, Giovanni¹  Tasara, Taurai²  Hottiger, Michael O.²  Hübscher, Ulrich² 

[1] IGBE-CNR, Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207, I-27100 Pavia, Italy;Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

关键词: Reverse transcription;    Integration;    Preintegration complex;    HIV-1;    human immunodeficiency virus type 1;    IN;    integrase;    LTR;    long terminal repeat;    PIC;    preintegration complex;    RT;    reverse transcriptase;   

DOI  :  10.1016/S0014-5793(01)02945-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.

【 授权许可】

Unknown