Down‐regulation of N‐myristoyl transferase expression in human T‐cell line CEM by human immunodeficiency virus type‐1 infection

FEBS Letters

Tanaka, Tadahiro¹  Misumi, Shogo¹  Takeuchi, Hiroki¹  Takamune, Nobutoki¹  Shoji, Shozo¹ 

[1] Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan

关键词: N-Myristoyl transferase;    Myristoylation;    Human immunodeficiency virus type-1;    HIV-1;    human immunodeficiency virus type-1;    hNMT;    human N-myristoyl transferase;    mAb;    monoclonal antibody;    MAP;    multiple antigen peptide;    ELISA;    enzyme-linked immunosorbent assay;    p.i.;    post-infection;   

DOI  :  10.1016/S0014-5793(01)02892-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study focuses on the expression level of N-myristoyl transferase (NMT) in the course of human immunodeficiency virus type-1 (HIV-1) infection. HIV-1 structural proteins were gradually expressed during the process of infection of the human T-cell line CEM, whereas the expression levels of NMT subsequently decreased under the same conditions. In addition, the chronically HIV-1-infected T-cell line CEM/LAV-1 exhibited low expression levels of NMT. We hypothesize that the decrease in the expression level of NMT due to HIV-1 infection may be related to the virus’ strategy that leads to its persistent replication.

【 授权许可】

Unknown