A new FACIT of the collagen family: COL21A1

FEBS Letters

Fitzgerald, Jamie¹  Bateman, John F.¹ 

[1] Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Vic. 3052, Australia

关键词: Fibril-associated collagen with interrupted triple helices;    von Willebrand factor A-domain;    Thrombospondin repeat;    Interrupted collagen triple helix;    Extracellular matrix;    FACIT;    fibril-associated collagen with interrupted triple helices;    ECM;    extracellular matrix;    VA;    von Willebrand factor A-domain;    TN;    thrombospondin domain;    COL;    collagenous domain;    NC;    non-collagenous domain;    MTE;    multiple tissue expression;    PCR;    polymerase chain reaction;   

DOI  :  10.1016/S0014-5793(01)02754-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12.

【 授权许可】

Unknown