Re‐examination of the mechanisms regulating nuclear inositol lipid metabolism

FEBS Letters

Martelli, Alberto M.¹  Cocco, Lucio¹  Narducci, Paola²  Aluigi, Michela¹  Tabellini, Giovanna²  Peruzzi, Daniela¹  Bareggi, Renato²  Bortul, Roberta² 

[1] Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia, Università di Bologna, via Irnerio 48, 40126 Bologna, Italy;Dipartimento di Morfologia Umana Normale, Università di Trieste, via Manzoni 16, 34138 Trieste, Italy

关键词: Nucleus;    Inositol lipid;    Phosphatidylinositol 3-kinase;    G protein;    Phospholipase C-β1;    Phosphorylation;    Mitogen-activated protein kinase;    Protein kinase C;    DAG;    1;    2-diacylglycerol;    IGF-I;    insulin-like growth factor-I;    Ins(1;    4;    5)P3;    inositol 1;    4;    5-trisphosphate;    MAP;    mitogen-activated protein;    MEL;    mouse erythroleukemia;    NGF;    nerve growth factor;    PH;    pleckstrin homology;    PKA;    protein kinase A;    PKC;    protein kinase C;    PI-PLC;    phosphoinositide-specific phospholipase C;    PIKE;    phosphoinositide kinase enhancer;    PtdIns(4;    5)P2;    phosphatidylinositol 4;    5-bisphosphate;    PI3K;    phosphatidylinositol 3-kinase;    PtdIns(3;    4;    5)P3;    phosphatidylinositol 3;    4;    5-trisphosphate;   

DOI  :  10.1016/S0014-5793(01)02752-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Although inositol lipids constitute only a very minor proportion of total cellular lipids, they have received immense attention by scientists since it was discovered that they play key roles in a wide range of important cellular processes. In the late 1980s, it was suggested that these lipids are also present within the cell nucleus. Albeit the early reports about the intranuclear localization of phosphoinositides were met by skepticism and disbelief, compelling evidence has subsequently been accumulated convincingly showing that a phosphoinositide cycle is present at the nuclear level and may be activated in response to stimuli that do not activate the inositol lipid metabolism localized at the plasma membrane. Very recently, intriguing new data have highlighted that some of the mechanisms regulating nuclear inositol lipid metabolism differ in a substantial way from those operating at the cell periphery. Here, we provide an overview of recent findings regarding the regulation of both nuclear phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C-β1.

【 授权许可】

Unknown