Identification of rod‐ and cone‐specific phosducins in teleost retinas

FEBS Letters

Satoh, Takunori¹  Tokunaga, Fumio¹  Kobayashi, Yuko¹  Hisatomi, Osamu¹ 

[1] Department of Earth and Space Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan

关键词: Phosducin;    Photoreceptor cell;    Retina;    Teleost;    Medaka (Oryzias latipes);   

DOI  :  10.1016/S0014-5793(01)02670-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phosducin (PD) is a regulatory protein of vertebrate phototransduction cascades. In mammalian retina, it has been thought that only one kind of PD commonly exists in both rods and cones. However, we have found two kinds of PD (OlPD-R and OlPD-C) in the retina of a teleost, medaka (Oryzias latipes). In situ hybridization and immunohistochemical analysis demonstrated that OlPD-R and -C are selectively expressed in rods and cones, respectively. The antiserum against medaka PDs recognized two kinds of proteins in bluegill (Lepomis macrochirus) retina. These results suggest that rod- and cone-specific PDs exist in teleost retinas, probably creating differences in light adaptation between rods and cones.

【 授权许可】

Unknown