The rules and roles of nucleocytoplasmic shuttling proteins

FEBS Letters

Carmo-Fonseca, Maria¹  Gama-Carvalho, Margarida¹ 

[1] Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal

关键词: Nucleocytoplasmic transport;    Nuclear import;    Nuclear export;    Shuttling protein;   

DOI  :  10.1016/S0014-5793(01)02487-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The spatial separation of mRNA synthesis from translation, while providing eukaryotes with the possibility to achieve higher complexity through a more elaborate regulation of gene expression, has set the need for transport mechanisms through the nuclear envelope. In a simplistic view of nucleocytoplasmic transport, nuclear proteins are imported into the nucleus while RNAs are exported to the cytoplasm. The reality is, however, that transport of either proteins or RNAs across the nuclear envelope can be bi-directional. During the past years, an increasing number of proteins have been identified that shuttle continuously back and forth between the nucleus and the cytoplasm. The emerging picture is that shuttling proteins are key factors in conveying information on nuclear and cytoplasmic activities within the cell.

【 授权许可】

Unknown