Arginine kinase of the flagellate protozoa Trypanosoma cruzi

FEBS Letters

Gerez de Burgos, Nelia M¹  Cochella, Luisa²  Ivaldi, M.Soledad²  Pereira, Claudio A²  Torres, Héctor N²  Remedi, Marı́a S¹  Alonso, Guillermo D²  Flawiá, Mirtha M²  Paveto, M.Cristina² 

[1] Cátedra de Quı́mica Biológica, Facultad de Medicina. Universidad Nacional de Córdoba, Córdoba, Argentina;Instituto de Investigaciones en Ingenierı́a Genética y Biologı́a Molecular, Consejo Nacional de Investigaciones Cientı́ficas y Técnicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

关键词: Phosphagen;    Arginine kinase;    Guanidino kinase;    Phosphoarginine;    Trypanosoma cruzi;   

DOI  :  10.1016/S0014-5793(01)02473-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In epimastigotes of Trypanosoma cruzi, the etiological agent of Chagas’ disease, arginine kinase activity increased continuously during the exponential phase of growth. A correlation between growth rate, enzyme-specific activity and enzyme protein was observed. Arginine kinase-specific activity, expressed as a function of enzyme protein, remains roughly constant up to 18 days of culture. In the whole range of the culture time mRNA levels showed minor changes indicating that the enzyme activity is post-transcriptionally regulated. Arginine kinase could be proposed as a modulator of energetic reserves under starvation stress condition.

【 授权许可】

Unknown