UV‐light‐dependent binding of a visual arrestin 1 isoform to photoreceptor membranes in a neuropteran (Ascalaphus) compound eye

FEBS Letters

Gerdon, Gabriele²  Draslar, Kazimir¹  Schillo, Markus²  Paulsen, Reinhard²  Bentrop, Joachim² 

[1] Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, SL-1000 Ljubljana, Slovenia;Lehrstuhl für Zell- und Neurobiologie, Zoologisches Institut, Universität Karlsruhe, Haid-und-Neustr. 9, D-76131 Karlsruhe, Germany

关键词: Arrestin;    UV-absorbing rhodopsin;    Light-dependent arrestin binding;    Vision;    Sensory cell;    Am;    Ascalaphus macaronius;    Arr1;    arrestin 1;    Arr2;    arrestin 2;    Cv;    Calliphora vicina;    Dm;    Drosophila melanogaster;    GPCR;    G-protein-coupled receptor;    Hv;    Heliothis virescens;    M;    metarhodopsin;    P;    rhodopsin;   

DOI  :  10.1016/S0014-5793(01)02287-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Arrestins are regulators of the active state of G-protein-coupled receptors. Towards elucidating the function of different arrestin subfamilies in sensory cells, we have isolated a novel arrestin 1, Am Arr1, from the UV photoreceptors of the neuropteran Ascalaphus macaronius. Am Arr1 forms a phylogenetic clade with antennal and visual Arr1 isoforms of invertebrates. Am Arr1 undergoes a light-dependent binding cycle to photoreceptor membranes, as reported earlier only for members of the arrestin 2 subfamily. This suggests a common control mechanism for the active state of invertebrate rhodopsins and G-protein-coupled receptors of antennal sensory cells. Furthermore, it implies that a strict correlation of distinct arrestin isoforms to distinct functions is not a general principle for invertebrate sensory cells.

【 授权许可】

Unknown