Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast

FEBS Letters

Dewaste, Valérie¹  Dubois, Evelyne²  Erneux, Christophe¹  Messenguy, Francine² 

[1] Interdisciplinary Research Institute (IRIBHN), Université Libre de Bruxelles, Campus Erasme Building C, 808 Route de Lennik, B-1070 Brussels, Belgium;Laboratoire de Microbiologie, Institut de Recherches Microbiologiques J.M. Wiame, Université Libre de Bruxelles, 1 Avenue Emile Gryzon, B-1070 Brussels, Belgium

关键词: Arg82;    Arginine metabolism;    Inositol polyphosphate multikinase;    Yeast;   

DOI  :  10.1016/S0014-5793(00)02318-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Arg82, a nuclear regulator of diverse cellular processes in yeast, is an inositol polyphosphate kinase. Some defects such as the regulation of arginine metabolism observed in an arg82Δ, result from a lack of Mcm1 and Arg80 stability. We show here that neither the kinase activity of Arg82 nor inositol phosphates are required for the control of arginine metabolism. Arg82 mutations keeping kinase active affect the expression of arginine genes, whereas mutations in the kinase domain do not impair this metabolic control.

【 授权许可】

Unknown