Consensus predictions of membrane protein topology

FEBS Letters

Nilsson, Johan¹  von Heijne, Gunnar¹  Persson, Bengt¹ 

[1] Stockholm Bioinformatics Center, Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden

关键词: Membrane protein;    Topology;    Prediction;    Bioinformatics;   

DOI  :  10.1016/S0014-5793(00)02321-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have explored the possibility that consensus predictions of membrane protein topology might provide a means to estimate the reliability of a predicted topology. Using five current topology prediction methods and a test set of 60 Escherichia coli inner membrane proteins with experimentally determined topologies, we find that prediction performance varies strongly with the number of methods that agree, and that the topology of nearly half of all E. coli inner membrane proteins can be predicted with high reliability (>90% correct predictions) by a simple majority-vote approach.

【 授权许可】

Unknown