Original involvement of antimicrobial peptides in mussel innate immunity

FEBS Letters

Roch, Philippe²  Mitta, Guillaume²  Vandenbulcke, Franck¹ 

[1] Laboratoire d'Endocrinologie des Annélides, UPRES A 8017, Université de Lille 1, Lille, France;Défense et Résistance chez les Invertébrés Marins (DRIM), UMR 5098, Université de Montpellier 2, cc 80, Place E. Bataillon, 34095 Montpellier, France

关键词: Antimicrobial peptide;    Defensin;    Mytilin;    Myticin;    Innate immunity;    Mussel;    Mollusc;   

DOI  :  10.1016/S0014-5793(00)02192-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, the existence and extended diversity of antimicrobial peptides has been revealed in two mussel species. These molecules are classified into four groups according to common features of their primary structure: defensins, mytilins, myticins and mytimycin. In Mytilus galloprovincialis, gene structure reveals synthesis as precursors in circulating hemocytes. Synthesised even in absence of challenge, the precursors mature and the peptides are stored in granules as active forms. The different peptides are engaged in the destruction of bacteria inside phagocytes, before being released into hemolymph to participate in systemic responses. Such involvement in anti-infectious responses is unique, and apparently more related to those of mammalian phagocytes than to those of insects.

【 授权许可】

Unknown