Trp12, a novel Trp related protein from kidney

FEBS Letters

Flockerzi, Veit¹  Wissenbach, Ulrich¹  Bödding, Matthias¹  Freichel, Marc¹ 

[1] Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, D-66421 Homburg, Germany

关键词: Transient receptor potential;    Osmoregulation;    Calcium channel;    Cation channel;    Capacitative calcium entry;   

DOI  :  10.1016/S0014-5793(00)02212-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified. The Trp12 mRNA is abundantly expressed in mouse kidney and encodes a protein of 871 amino acid residues. Trp12 transfected cells reveal an elevated cytosolic Ca²⁺ and respond with a further increase of cytosolic Ca²⁺ to perfusion with hypoosmotic solutions. The human orthologue of murine Trp12 was localized on a genomic clone derived from human chromosome 12. It is composed of 15 translated exons. The intron placement within that primary structure does not correlate with the previously postulated splice sites in transcripts encoding the stretch-inhibitable channel which shares a high degree of amino acid sequence identity with Trp12 and the vanilloid receptor type 1.

【 授权许可】

Unknown