The mitochondrial inner membrane AAA metalloprotease family in metazoans

FEBS Letters

Grivell, Leslie A.²  Shah, Zahid H.¹  Jacobs, Howard T.¹  Juhola, M.Katariina¹ 

[1] Institute of Medical Technology and Tampere University Hospital, 33014 Tampere, Finland;Swammerdam Institute of Life Sciences, Section for Molecular Biology, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands

关键词: Metalloprotease;    AAA protein;    Chaperone;    Mitochondrion;   

DOI  :  10.1016/S0014-5793(00)01989-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Three metalloproteases belonging to the AAA superfamily (Yme1p, Afg3p and Rca1p) are involved in protein turnover and respiratory chain complex assembly in the yeast inner mitochondrial membrane. Analysis of the completed genome sequences of Caenorhabditis elegans and Drosophila melanogaster indicates that this gene family typically comprises 3–4 members in metazoans. Phylogenetic analysis reveals three main branches represented, respectively, by Saccharomyces cerevisiae YME1, human SPG7 (paraplegin) and S. cerevisiae AFG3 and RCA1. mt-AAA metalloproteases are weak candidates for several previously studied Drosophila mutants. A full elucidation of the cellular and physiological roles of mt-AAA metalloproteases in metazoans will require the creation of targeted mutations.

【 授权许可】

Unknown