C2PA, a new protein expressed during mouse spermatogenesis

FEBS Letters

Tomasetto, Catherine¹  Wendling, Corinne¹  Linares, José-Luis¹  Rio, Marie-Christine¹ 

[1] Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM U184/ULP BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France

关键词: C2PA;    Spermatogenesis;    C2 domain;    PDZ domain;   

DOI  :  10.1016/S0014-5793(00)01942-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

C2PA is a novel protein that contains a C2 membrane binding domain, a PDZ protein/protein interaction domain, and an ATP/GTP binding domain. C2PA is expressed during embryogenesis from 8.5 days post-coitum (dpc) until birth. After birth, C2PA expression is mainly observed in the post-natal and adult testis. During spermatogenesis, C2PA transcripts are specifically observed in the spermatocytes, whereas spermatogonia and spermatids are negative. Taken together, these results suggest that C2PA might be involved in cell signaling pathways occurring during spermatogenesis.

【 授权许可】

Unknown