Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain

FEBS Letters

Craxton, Molly¹  Goedert, Michel¹ 

[1] MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

关键词: Neurotransmission;    Synaptotagmin V;    C2 domain;    Ca2+ sensor;   

DOI  :  10.1016/0014-5793(95)00176-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Regulated Ca²⁺-dependent release of transmitters from synaptic vesicles is an important characteristic of chemical neurotransmission. Synaptotagmins are abundant synaptic vesicle transmembrane proteins that probably function as Ca²⁺ sensors. Molecular cloning has identified four different synaptotagmin isoforms in mammals. We report here the cloning and sequencing of a novel isoform of 386 amino acids. Synaptotagmin V is 54% identical in sequence to synaptotagmin I and possesses all the domains that characterise this multigene family. It is expressed at high levels in rat brain, but not in spinal cord or a number of peripheral non-neuronal tissues.

【 授权许可】

Unknown