Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony‐stimulating factor stimulation

FEBS Letters

Mouchiroud, Guy¹  Arnaud, Sylvie¹  Bourgin, Caroline¹  Bourette, Roland¹ 

[1] Centre de Génétique Moléculaire et Cellulaire, UMR CNRS 5534, Université Claude Bernard Lyon I, Batiment 741, 43, boulevard du 11 novembre 1918, 69622 Villeurbanne Cedex, France

关键词: Macrophage colony-stimulating factor receptor;    Mona;    Grb2;    Shc;    MAPK kinase;   

DOI  :  10.1016/S0014-5793(00)01906-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mona is an SH3 and SH2 domain-containing adapter molecule that is induced during monocytic differentiation. Here we have first shown that M-CSFR is the major Mona partner in M-CSF signaling, the interaction being mediated through tyrosine 697 of the receptor. Next we asked whether Mona expression would alter the Ras/MAP kinase pathway since Mona is a likely competitor of Grb2 for binding to M-CSFR. We found that M-CSF induced late and massive phosphorylation of ERK molecules in Mona-expressing myeloid cells compared to non-expressing cells. These results suggest that Mona expression might modify M-CSF signaling during monocytic differentiation.

【 授权许可】

Unknown