CD44v6 cell surface expression is a common feature of macrophages and macrophage‐like cells – implication for a natural macrophage extravasation mechanism mimicked by tumor cells

FEBS Letters

Braumüller, Heidi¹  Ramadani, Marco¹  Gansauge, Susanne¹  Gansauge, Frank¹ 

[1] Division of Molecular Oncology, University of Ulm, Steinhövelstr. 9, 89075 Ulm, Germany

关键词: Peripheral mononuclear cell;    Hl-60;    Differentiation;    CD44;    CD44v6;   

DOI  :  10.1016/S0014-5793(00)01737-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Soluble CD44standard (sCD44s) and CD44v6 (sCD44v6) cannot only be detected in sera of patients with pancreatic carcinoma but also of healthy blood donors. To investigate whether sCD44s and sCD44v6 are derived from white blood cells, we stimulated whole blood with phytohemagglutinin and interleukin-2, which induced expression of CD44v6 only on monocytes. For further investigations, we used the promyelocytic leukemia cell line Hl-60. Only Hl-60 cells differentiating along the macrophage pathway showed increased expression of CD44s and CD44v6. Furthermore, only macrophages showed increased secretion of sCD44s and sCD44v6. Our data suggest that CD44s and CD44v6 are common adhesion molecules on macrophages and macrophage-like cells.

【 授权许可】

Unknown