Ligand–protein interactions in nuclear receptors of hormones

FEBS Letters

Egea, Pascal F¹  Klaholz, Bruno P¹  Moras, Dino¹ 

[1]Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1, rue Laurent Fries, P.O. Box 163, F-67404 Illkirch Cedex, France

关键词: Nuclear receptor;    Ligand binding domain;    Transcriptional regulation;    Ligand–protein interaction;    Selectivity;    Molecular recognition;    AT-RA;    all-trans retinoic acid;    9C-RA;    9-cis retinoic acid;    NR;    nuclear receptor;    RAR;    retinoic acid receptor;    LBD;    ligand binding domain;   

DOI  :  10.1016/S0014-5793(00)01672-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.

【 授权许可】

Unknown