Chaperone‐like activity of synucleins

FEBS Letters

Souza, José M.²  Lee, Virginia M.-Y.¹  Ischiropoulos, Harry²  Giasson, Benoit I.¹ 

[1] Center for Neurodegenerative Diseases Research and Department of Pathology and Laboratory Medicine, The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA;Stokes Research Institute, Children's Hospital of Philadelphia and Department of Biochemistry and Biophysics, 416D Abramson Center, 34th Street and Civic Center Blvd., The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA

关键词: Parkinson's disease;    Lewy body;    Neurodegenerative disorder;   

DOI  :  10.1016/S0014-5793(00)01563-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Synucleins are a family of small proteins that are predominantly expressed in neurons. The functions of the synucleins are not entirely understood, but they have been implicated in the pathogenesis of several neurodegenerative diseases. Our data show that α-, β- or γ-synuclein suppresses the aggregation of thermally denatured alcohol dehydrogenase and chemically denatured insulin. The A53T but not the A30P mutant α-synuclein was able to inhibit the aggregation of insulin and the chaperone-like activity of α-synuclein was lost upon removal of its C-terminal residues 98–140. These results demonstrate that synucleins with the exception of the A30P mutant possess chaperone-like activity.

【 授权许可】

Unknown