Apelin peptides block the entry of human immunodeficiency virus (HIV)

FEBS Letters

Haraguchi, Yuji²  Hoshino, Hiroo²  Tatemoto, Kazuhiko¹  Zou, Min-Xu¹  Liu, Hui-Yu²  Soda, Yasushi² 

[1] Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan;Department of Virology and Preventive Medicine, Gunma University School of Medicine, Maebashi 371-8511, Japan

关键词: Human immunodeficiency virus;    Simian immunodeficiency virus;    Apelin;    APJ;    Coreceptor;   

DOI  :  10.1016/S0014-5793(00)01487-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the brain-derived NP-2/CD4 cells. Because apelin is an endogenous ligand for the APJ receptor, we examined the inhibitory effects of apelin peptides on HIV infection, and found that the apelin peptides inhibit the entry of some HIV-1 and HIV-2 into the NP-2/CD4 cells expressing APJ. The inhibitory efficiency has been found to be in the order of apelin-36>apelin-17>apelin-13>apelin-12.

【 授权许可】

Unknown