Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest

FEBS Letters

Chung, Jae Hoon¹  Lee, Young Jae¹  Hahn, Yoonsoo¹  Lee, Jieun¹  Yun, Ji Hye¹  Park, Jeongmin¹  Park, Chang Won¹  Hyun, Byunghwa² 

[1] Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea;Biological Resources Laboratory, Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon 306-600, South Korea

关键词: Imprinting;    Peg1/Mest;    Coatomer protein complex;    Antisense RNA;    Mit1;    Mest-linked imprinted transcript 1;    Copg;    coatomer protein complex subunit γ;   

DOI  :  10.1016/S0014-5793(00)01461-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues. Copg2 consists of 24 exons within the >40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2. In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3′-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues.

【 授权许可】

Unknown