Olive oil phenolics are dose‐dependently absorbed in humans

FEBS Letters

Caruso, Donatella³  Mattei, Alissa¹  Galli, Claudio³  Bornet, Francis²  Visioli, Francesco³  Galli, Giovanni³  Patelli, Rossana³ 

[1] Carapelli s.p.a., Florence, Italy;Eridania Béghin-Say, Vilvoorde, Belgium;Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy

关键词: Olive oil;    Phenol;    Atherosclerosis;    Mediterranean diet;    Antioxidant;    Hydroxytyrosol;   

DOI  :  10.1016/S0014-5793(00)01216-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Olive oil phenolic constituents have been shown, in vitro, to be endowed with potent biological activities including, but not limited to, an antioxidant action. To date, there is no information on the absorption and disposition of such compounds in humans. We report that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose-dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates. Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide.

【 授权许可】

Unknown