Peroxisome proliferator‐activated receptors are expressed in mouse bone marrow‐derived mast cells

FEBS Letters

Nakahata, Tatsutoshi²  Nonaka, Takashi¹  Komoriya, Keiji¹  Sugiyama, Hiroyuki¹  Kishimoto, Tadashi¹  Tsuji, Kohichiro² 

[1] Department of Pharmacological Research, Pharmaceuticals Development Laboratories, Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka Hino, Tokyo 191-8512, Japan;Department of Clinical Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai Minato-ku, Tokyo 108-8639, Japan

关键词: Peroxyzome proliferator-activated receptor;    Mast cell;    Cytokine;    PPAR;    peroxisome proliferator-activated receptor;    mBMMC;    mouse bone marrow-derived mast cell;    15d-PGJ2;    15-deoxy-Δ12;    14-prostaglandin J2;   

DOI  :  10.1016/S0014-5793(00)01169-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We examined the expression of peroxisome proliferator-activated receptors (PPARs) and the role of PPARs in cytokine production in mouse bone marrow-derived mast cells (mBMMCs). mBMMCs expressed PPARβ strongly and γ slightly, but not α. Activation of mBMMCs with antigen or calcium ionophore resulted in the increased expression of PPARγ mRNA specifically. 15-Deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂) and troglitazone, all PPARγ ligands, attenuated the antigen-induced cytokine production by mBMMCs. Carbaprostacyclin, a PPARβ ligand, also inhibited cytokine production, whereas PPARα ligands did not. These results suggest that PPARβ and γ might be included in the negative regulation of mast cell activation.

【 授权许可】

Unknown