FEBS Letters | |
Bcl‐2 family: Life‐or‐death switch | |
Shimizu, Shigeomi1  Tsujimoto, Yoshihide1  | |
[1] Department of Medical Genetics, Biomedical Research Center, Osaka University Graduate School of Medicine, CREST of Japan Science and Technology Corp. (JST), 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan | |
关键词: Apoptosis; Bcl-2; Mitochondrion; Cytochrome c; VDAC; | |
DOI : 10.1016/S0014-5793(99)01761-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The Bcl-2 family of proteins that consists of anti-apoptotic and pro-apoptotic members determines life-or-death of a cell by controlling the release of mitochondrial apoptogenic factors, cytochrome c and apoptosis-inducing factor (AIF), that activate downstream executional phases, including the activation of death proteases called caspases. Cytochrome c release is, thus, central to apoptotic signal transduction in mammals, making study of the mechanism for cytochrome c release a major issue. Several models for cytochrome c release have been proposed, including rupture of mitochondrial outer membrane and involvement of a specific channel. Here, we provide an overview of recent findings on the role of Bcl-2 family members in the life-or-death decision of a cell.
【 授权许可】
Unknown
【 预 览 】
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RO201912020308860ZK.pdf | 163KB | download |