FEBS Letters | |
The function of the microtubule‐associated protein tau is variably modulated by graded changes in glycogen synthase kinase‐3β activity | |
Lovestone, S.2  Menu, R.1  Brion, J.P.1  Conreur, J.L.1  Dayanandan, R.2  Anderton, B.H.2  Leroy, K.1  | |
[1] Laboratory of Pathology and Electron Microscopy, Université Libre de Bruxelles, School of Medecine, 808, route de Lennik, Bldg C-10, 1070 Brussels, Belgium;Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK | |
关键词: Tau; Glycogen synthase kinase-3β; Microtubule; Cell process; Phosphorylation; Lithium; GSK-3β; glycogen synthase kinase-3β; CHO; Chinese hamster ovary; | |
DOI : 10.1016/S0014-5793(99)01720-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The microtubule-associated protein tau favors microtubule nucleation and stabilization and plays a role in the elongation of axons. We have investigated the ability of glycogen synthase kinase-3β (GSK-3β) to control tau-induced processes outgrowth. Tau-transfected Chinese hamster ovary (CHO) cells developed processes containing microtubule bundles after cytochalasin treatment, but a significant reduction in the number of cells harboring processes was observed in tau/GSK-3β-co-transfected cells. Lithium, an inhibitor of GSK-3β, counteracted in a dose-dependent manner this inhibitory effect of GSK-3β. These findings suggest that GSK-3β modulates in a graded manner the ability of tau to control the microtubule-dependent induction of cell processes.
【 授权许可】
Unknown
【 预 览 】
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