Meprin mRNA in rat intestine during normal and glucocorticoid‐induced maturation: divergent patterns of expression of α and β subunits

FEBS Letters

Hahn, Dagmar¹  Henning, Susan J.²  Sterchi, Erwin E.¹  Lottaz, Daniel¹  Oesterreicher, Thomas J.²  Osterholm, Doreen E.² 

[1] Institute of Biochemistry and Molecular Biology and Department of Pediatrics, University of Berne, Buehlstrasse 28, CH-3010 Berne, Switzerland;Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA

关键词: Metalloendopeptidase;    Meprin;    Development;    mRNA expression;    Glucocorticoid;    Rat intestine;    P;    postnatal day;    EF;    elongation factor-1α;    ANOVA;    analysis of variance;   

DOI  :  10.1016/S0014-5793(99)01558-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Meprin is a zinc-metalloendopeptidase expressed in intestinal epithelial cells. In rat jejunum collected from postnatal day 4 (P4) through P25 meprins α mRNA exhibited uniform levels for the first three postnatal weeks and then declined, whereas meprin β mRNA showed a biphasic pattern with high levels in the first postnatal week followed by low levels from P7 through P19 and then a marked rise at P22 and P25. Dexamethasone treatment beginning at P10 had no significant effect on levels of meprins α mRNA, whereas this treatment caused a precocious increase in expression of meprin β mRNA. These divergent patterns of expression of meprins α and β mRNA suggest distinct roles for the two subunits during the suckling and weaning phases of rodent intestinal development.

【 授权许可】

Unknown