FEBS Letters | |
Urinary thymine dimers and 8‐oxo‐2′‐deoxyguanosine in psoriasis | |
Evans, Mark D.1  Bleiker, Tanya O.1  Hussieni, Amina1  Cooke, Marcus S.1  Ahmad, Jabeen1  Patel, Kayuri1  Burd, Robert M.1  Lunec, Joseph1  Hutchinson, Peter E.1  | |
[1] Division of Chemical Pathology, Centre for Mechanisms of Human Toxicity, PO Box 138, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK | |
关键词: PUVA; 8-Oxo-2′-deoxyguanosine; Thymine dimer; Psoriasis; Antibody; Urine; UVC-poly(dT); UVC-irradiated polythymidylic acid; PUVA; psoralen+ultraviolet A; T〈〉T; thymine dimer; 8-OHdG; 8-oxo-2′-deoxyguanosine; NER; nucleotide excision repair; UVR; ultraviolet radiation; | |
DOI : 10.1016/S0014-5793(99)01402-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Psoralen in conjunction with UVA (PUVA) is perhaps the most effective treatment for psoriasis. It is, however, a risk factor for skin cancer in these patients and there is a need to develop non-invasive assays reflective of treatment-induced DNA damage. We report here the assessment of two important lesions, thymine dimer (T〈〉T) and 8-oxo-2′-deoxyguanosine (8-OHdG), in the urine of psoriasis patients. It was found that, once corrected for urine concentration, the psoriatic group had significantly higher (P<0.0001) urinary levels of thymine dimers compared to the control group. No significant differences in urinary 8-OHdG levels were noted between the psoriatic, atopic dermatitis and control groups. Therefore biomonitoring of therapy from the very start with this simple and non-invasive assay could perhaps be an effective measure of the risk involved with the treatment allowing optimization for minimal-risk therapy.
【 授权许可】
Unknown
【 预 览 】
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RO201912020308540ZK.pdf | 93KB | download |