A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

FEBS Letters

Iida, Shin-ichi¹  Nishiyama, Yasuyuki¹  Kitamura, Nobuo³  Morisaki, Tetsuro¹  Hara, Toshihiro¹  Hirota, Toru¹  Makino, Keishi¹  Marumoto, Tomotoshi¹  Hiraoka, Takehisa³  Yamamoto, Hideyuki²  Saya, Hideyuki¹ 

[1] Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan;Department of Pharmacology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan;The 1st Department of Surgery, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan

关键词: Centrosome;    Mitotic spindle;    Cdc2;    Midbody;    Nocodazole;    Chromosome 6q;   

DOI  :  10.1016/S0014-5793(99)01224-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.

【 授权许可】

Unknown