Activation of channel activity of the NMDA receptor‐PSD‐95 complex by guanylate kinase‐associated protein (GKAP)

FEBS Letters

Yamada, Yasue²  Chochi, Yasuyo²  Sobue, Kenji¹  Ko, Ji-Ae²  Inui, Makoto² 

[1] Department of Neurochemistry and Neuropharmacology, Osaka University Medical School, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan;Department of Pharmacology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

关键词: N-Methyl-D-aspartate receptor;    Guanylate kinase-associated protein;    PSD-95;    Channel activity;    Xenopus oocyte;   

DOI  :  10.1016/S0014-5793(99)01171-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The channel-associated protein PSD-95 functionally modulates NMDA receptor channels, interacting with the channels via PDZ domain of PSD-95. PSD-95 also interacts with guanylate kinase-associated protein (GKAP) through the guanylate kinase-like domain of PSD-95. Here we report that GKAP markedly potentiates the channel activity of the receptor-PSD-95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD-95-induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD-95 quantitatively, which may make signal transmission more efficient at postsynaptic sites.

【 授权许可】

Unknown