Fibre type specificity of haem oxygenase‐1 induction in rat skeletal muscle

FEBS Letters

Motterlini, R.¹  Vesely, M.J.J.²  Green, C.J.²  Sanders, R.² 

[1] Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, Middlesex, UK;RAFT Institute of Plastic Surgery, Leopold Muller Building, Mount Vernon Hospital, Northwood HA6 2RN, Middlesex, UK

关键词: Heme oxygenase;    Skeletal muscle;    Fiber type;    Nitric oxide;    Carbon monoxide;    Ischemia;    HO-1;    haem oxygenase-1;    NO;    nitric oxide;    CO;    carbon monoxide;    EDL;    extensor digitorum longus muscle;    GAPDH;    glyceraldehyde 3-phosphate dehydrogenase;    HSPs;    heat shock proteins;   

DOI  :  10.1016/S0014-5793(99)01129-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of the inducible haem oxygenase (HO-1) gene was examined in different skeletal muscles. Rats were treated with haemin and a time course of HO-1 mRNA expression was determined in soleus and extensor digitorum longus (EDL) muscles. Fibre type composition and tissue myoglobin content were also measured. We found that HO-1 mRNA expression markedly increased in soleus (type I fibres) muscle but was only slightly affected in EDL (type II fibres). HO-1 expression directly correlated with both percentage of red fibres and tissue myoglobin. These data demonstrate that HO-1 gene expression follows a fibre type-specific pattern which might indicate an important role for this protein in the maintenance of skeletal muscle function.

【 授权许可】

Unknown