R‐esp1, a rat homologue of Drosophila Groucho, is differentially expressed after optic nerve crush and mediates NGF‐induced survival of PC12 cells

FEBS Letters

Bank, Ute³  Arndt, Marco³  Lendeckel, Uwe¹  Frank, Karin¹  Sabel, Bernhard A.²  Ansorge, Siegfried¹ 

[1] Institute of Experimental Internal Medicine, Centre of Internal Medicine, Otto von Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany;Institute of Medical Psychology, Otto von Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany;Institute of Immunology, Otto von Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany

关键词: Signaling;    Transcription factor;    Neurotrophin;   

DOI  :  10.1016/S0014-5793(99)01052-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The differential display reverse transcription polymerase chain reaction method was used to detect alterations in gene expression in the superior colliculus after optic nerve crush in adult rats. One of the most prominent changes observed was the selective induction of R-esp1, a homologue of the Drosophila enhancer of split locus (Groucho). Therefore, we studied the influence of R-esp1 on nerve growth factor (NGF)-induced cell survival of PC12 cells. Overexpression of R-esp1 promotes cell survival even in the absence of NGF and, conversely, it is reduced by antisense-mediated inhibition of R-esp1 expression. In conclusion, we propose a novel model in which R-esp1 protein mediates the NGF-signaling pathway.

【 授权许可】

Unknown