The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein

FEBS Letters

Tani, Masachika¹  Yokota, Jun¹  Watanabe, Hideomi³  Nagamachi, Yasuhiro¹  Ohwada, Susumu²  Shimizu, Kimihiro¹  Shiroishi, Toshihiko⁵  Raz, Avraham⁴  Niinaka, Yasufumi⁴ 

[1] Biology Division, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan;Second Department of Surgery, Gunma University School of Medicine, 39-22, Showa-machi 3-chome, Maebashi, Gunma 371-8511, Japan;Department of Orthopedic Surgery, Gunma University School of Medicine, 39-22, Showa-machi 3-chome, Maebashi, Gunma 371-8511, Japan;Tumor Progression and Metastasis Research Program, Karmanos Cancer Institute, 110 East Warren, Detroit, MI 48201, USA;Department of Mammalian Genetics Laboratory, National Institute of Genetics, 1-111, Tanida, Mishima, Shizuoka 441-8540, Japan

关键词: Autocrine motility factor receptor;    RING-H2;    Leucine zipper;    Seven transmembrane;    Expressed sequence tag;   

DOI  :  10.1016/S0014-5793(99)00966-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Autocrine motility factor receptor (AMFR) is a cell surface glycoprotein of molecular weight 78 000 (gp78), mediating cell motility signaling in vitro and metastasis in vivo. Here, we cloned the full-length cDNAs for both human and mouse AMFR genes. Both genes encode a protein of 643 amino acids containing a seven transmembrane domain, a RING-H2 motif and a leucine zipper motif and showed a 94.7% amino acid sequence identity to each other. Analysis of the amino acid sequence of AMFR with protein databases revealed no significant homology with all known seven transmembrane proteins, but a significant structural similarity to a hypothetical protein of Caenorhabditis elegans, F26E4.11. Thus, AMFR is a highly conserved gene which encodes a novel type of seven transmembrane protein.

【 授权许可】

Unknown