Evolutionary aspects of inorganic pyrophosphatase

FEBS Letters

Salminen, Anu¹  Cooperman, Barry S.²  Sivula, Toni¹  Lahti, Reijo¹  Baykov, Alexander A.³  Pohjanjoki, Pekka¹  Goldman, Adrian¹  Parfenyev, Alexey N.³ 

[1]Department of Biochemistry, University of Turku, FIN-20500 Turku, Finland

[2]Department of Chemistry, University of Pennsylvania, Pennsylvania, PA 19104-6323, USA

[3]A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119899, Russia

关键词: Pyrophosphatase;    Evolution;    Gene;    Primary structure;    PPase;    inorganic pyrophosphatase;    E-PPase;    Escherichia coli pyrophosphatase;    Y-PPase;    cytoplasmic pyrophosphatase of Saccharomyces cerevisiae;   

DOI  :  10.1016/S0014-5793(99)00779-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Based on the primary structure, soluble inorganic pyrophosphatases can be divided into two families which exhibit no sequence similarity to each other. Family I, comprising most of the known pyrophosphatase sequences, can be further divided into prokaryotic, plant and animal/fungal pyrophosphatases. Interestingly, plant pyrophosphatases bear a closer similarity to prokaryotic than to animal/fungal pyrophosphatases. Only 17 residues are conserved in all 37 pyrophosphatases of family I and remarkably, 15 of these residues are located at the active site. Subunit interface residues are conserved in animal/fungal but not in prokaryotic pyrophosphatases.

【 授权许可】

Unknown