A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

FEBS Letters

Lundwall, Åke¹  Lazure, Claude¹ 

[1] Department of Clinical Chemistry, Lund University, Malmö University Hospital, S-214 01 Malmö, Sweden

关键词: Semen;    Protein;    Rapid;    Exon;    Gene;    Evolution;   

DOI  :  10.1016/0014-5793(95)01076-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3′ non-translated nucleotides. The first and and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.

【 授权许可】

Unknown