High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression

FEBS Letters

Palm, Dieter²  Riederer, Peter¹  Schinzel, Reinhard²  Münch, Gerald²  Neumann, Arne² 

[1] Clinical Neurochemistry, Department of Psychiatry, Füchsleinstrasse 15, 97080 Würzburg, Germany;Physiological Chemistry I, Biocenter, Am Hubland, 97074 Würzburg, Germany

关键词: Hyaluronic acid;    Signal transduction;    Advanced glycation endproduct;    AGE;    advanced glycation endproduct;    IL-1α;    interleukin 1α;    IL-6;    interleukin 6;    TNF;    tumor necrosis factor;    HA;    hyaluronic acid;    LMW;    low molecular weight;    HMW;    high molecular weight;   

DOI  :  10.1016/S0014-5793(99)00731-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Advanced glycation endproducts (AGEs), which accumulate on long-lived proteins and protein deposits (amyloids), induce the expression of proinflammatory cytokines through NF-κB-dependent pathways. Hyaluronic acid with a molecular weight above 1.2 MDa (HMW-HA) inhibits the AGE-induced activation of the transcription factor NF-κB and the NF-κB-regulated cytokines interleukin-1α, interleukin-6 and tumor necrosis factor-α. Since the molecular weight of hyaluronic acid in humans decreases with age and under conditions of oxidative stress, it is likely that the protective effect of HMW-HA against AGE-induced cellular activation is lost at sites of chronic inflammation and in older age.

【 授权许可】

Unknown