FEBS Letters | |
High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression | |
Palm, Dieter2  Riederer, Peter1  Schinzel, Reinhard2  Münch, Gerald2  Neumann, Arne2  | |
[1] Clinical Neurochemistry, Department of Psychiatry, Füchsleinstrasse 15, 97080 Würzburg, Germany;Physiological Chemistry I, Biocenter, Am Hubland, 97074 Würzburg, Germany | |
关键词: Hyaluronic acid; Signal transduction; Advanced glycation endproduct; AGE; advanced glycation endproduct; IL-1α; interleukin 1α; IL-6; interleukin 6; TNF; tumor necrosis factor; HA; hyaluronic acid; LMW; low molecular weight; HMW; high molecular weight; | |
DOI : 10.1016/S0014-5793(99)00731-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Advanced glycation endproducts (AGEs), which accumulate on long-lived proteins and protein deposits (amyloids), induce the expression of proinflammatory cytokines through NF-κB-dependent pathways. Hyaluronic acid with a molecular weight above 1.2 MDa (HMW-HA) inhibits the AGE-induced activation of the transcription factor NF-κB and the NF-κB-regulated cytokines interleukin-1α, interleukin-6 and tumor necrosis factor-α. Since the molecular weight of hyaluronic acid in humans decreases with age and under conditions of oxidative stress, it is likely that the protective effect of HMW-HA against AGE-induced cellular activation is lost at sites of chronic inflammation and in older age.
【 授权许可】
Unknown
【 预 览 】
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RO201912020307888ZK.pdf | 212KB | download |