Uncoupling protein‐3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non‐esterified fatty acids

FEBS Letters

Brun, S¹  Iglesias, R¹  Viñas, O¹  Giralt, M¹  Carmona, M.C¹  Villarroya, F¹  Mampel, T¹ 

[1] Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain

关键词: Skeletal muscle;    Uncoupling protein-3;    Development;    Gene expression;    UCP2;    uncoupling protein-2;    UCP3;    uncoupling protein-3;   

DOI  :  10.1016/S0014-5793(99)00722-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uncoupling protein-3 gene expression in skeletal muscle is up-regulated during postnatal development of mice. A high-carbohydrate diet at weaning induces a decrease in uncoupling protein-3 mRNA levels that does not occur when mice were weaned onto a high-fat diet. Uncoupling protein-3 mRNA levels do not increase in response to fasting in young pups. Only after day 15 of life, when fasting increases serum non-esterified fatty acids, uncoupling protein-3 mRNA is up-regulated by starvation. Over-nutrition or under-nutrition during lactation increases or decreases, respectively, uncoupling protein-3 mRNA expression in skeletal muscle. Regulation of uncoupling protein-3 gene expression in skeletal muscle during development is mediated by ontogenic and nutritional factors determining changes in circulating non-esterified fatty acids.

【 授权许可】

Unknown