Action of thyroid hormones at the cellular level: the mitochondrial target

FEBS Letters

Goglia, Fernando¹  Lanni, Antonia¹  Moreno, Maria¹ 

[1] Dipartimento di Fisiologia Generale ed Ambientale, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy

关键词: Thyroid hormone;    Diiodothyronine;    Mitochondrion;    Receptor;    Uncoupling protein;    Energy metabolism;    T3;    triiodo-L-thyronine;    T4;    thyroxine;    3;    5-T2;    3;    5-diiodo-L-thyronine;    3;    3′-T2;    3;    3′-diiodo-L-thyronine;    RCR;    respiratory control ratio;    State 3;    respiratory state in which ATP synthesis is at the maximal rate;    State 4;    respiratory state in which there is no ATP synthesis;    UCP;    uncoupling protein;    TR;    nuclear T3 receptor;    TRE;    thyroid hormone response element;    mtTFA;    mitochondrial transcription factor A;    NRF-1;    nuclear respiratory factor;    mtDNA;    mitochondrial DNA;    p43;    mitochondrial matrix T3-binding protein;    PTU;    6-n-propylthiouracil;    IOP;    iopanoic acid;    COX;    cytochrome c-oxidase;    RM;    resting metabolic rate;   

DOI  :  10.1016/S0014-5793(99)00642-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Thyroid hormones exert profound effects on the energy metabolism. An inspection of the early and more recent literature shows that several targets at the cellular level have been identified. Since their effects on the nuclear signalling pathway have already been well-defined and extensively reviewed, this article focuses on the regulation of mitochondrial activity by thyroid hormones. Mitochondria, by virtue of their biochemical functions, are a natural candidate as a direct target for the calorigenic effects of thyroid hormones. To judge from results coming from various laboratories, it is quite conceivable that mitochondrial activities are regulated both directly and indirectly. Not only triiodo-L-thyronine, but also diiodothyronines are active in regulating the energy metabolism. They influence the resting metabolism in rats with 3,5-diiodo-L-thyronine seeming to show a clearer effect.

【 授权许可】

Unknown