Thermodynamic influences on the fidelity of iron‐sulphur cluster formation in proteins

FEBS Letters

Armstrong, Fraser A¹  Williams, Robert J.P¹ 

[1] Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, UK

关键词: Iron-sulfur;    Ferredoxin;    Homeostasis;    Cluster;   

DOI  :  10.1016/S0014-5793(99)00545-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In an organism, two thermodynamic factors are important in ensuring that homometallic [4Fe-4S] cubane clusters are formed in preference to clusters containing heterometals such as Zn or Cu. These are the electronic resonance stabilisation, which boosts the binding of Fe(II) within an Fe-S cluster relative to its normally low position in the Irving-Williams order, and attenuation of the cytoplasmic concentrations of competing metals such as Zn or Cu by specific ligands.

【 授权许可】

Unknown