Mutation patterns for two flaviviruses: hepatitis C virus and GB virus C/hepatitis G virus

FEBS Letters

Mizokami, Masashi¹  Ikeo, Kazuho³  Nakano, Tatsunori¹  Suzuki, Yoshiyuki³  Kumada, Takashi⁴  Iino, Shiro²  Imanishi, Tadashi³  Ueda, Ryuzo¹  Orito, Etsuro¹ 

[1] Second Department of Medicine, Nagoya City University Medical School, Nagoya 467-8601, Japan;Department of Medicine, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan;Center for Information Biology, National Institute of Genetics, Mishima 411-8540, Japan;Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki 503-8502, Japan

关键词: Mutation pattern;    Relative substitution frequency;    Phylogenetic tree;    Hepatitis C virus;    GB virus C/hepatitis G virus;    HCV;    hepatitis C virus;    HGV;    GB virus C/hepatitis G virus;    HIV;    human immunodeficiency virus;    RT;    Reverse transcriptase;    AZT;    3′-azido-2′;    3′-dideoxythymidine;   

DOI  :  10.1016/S0014-5793(99)00507-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We studied the mutation patterns of hepatitis C virus (HCV) and GB virus C/hepatitis G virus (HGV). Although the mutation patterns of the two viruses were similar to each other, they were quite different from that of HIV. In particular, the similarity of the patterns between HCV or HGV and human nuclear pseudogenes was statistically significant whereas there was no similarity between HIV and human nuclear pseudogenes. This finding suggests that the mutation patterns of HCV and HGV are similar to the patterns of spontaneous substitution mutations of human genes, implying that nucleotide analogues which are effective against HCV and HGV may have a side effect on the normal cells of humans.

【 授权许可】

Unknown