Absorption and metabolism of cyanidin 3‐O‐β‐D‐glucoside in rats

FEBS Letters

Horio, Fumihiko²  Osawa, Toshihiko²  Tsuda, Takanori¹ 

[1] Tokaigakuen Women's College, 2-901 Nakahira, Tenpaku-ku, Nagoya 468-8514, Japan;Department of Applied Biological Sciences, Nagoya University, Nagoya 464-0814, Japan

关键词: Anthocyanin;    Cyanidin 3-O-β-D-glucoside;    Antioxidant;    Absorption;    Metabolism;    C3G;    cyanidin 3-O-β-D-glucoside;    COMT;    catechol-O-methyltransferase;    Cy;    cyanidin;    FAB-MS;    fast atom bombardment mass spectrometry;    HPLC;    high-performance liquid chromatography;    LDL;    low-density lipoprotein;    PC;    protocatechuic acid;    TFA;    trifluoroacetic acid;    UV;    ultraviolet;    VIS;    visible;   

DOI  :  10.1016/S0014-5793(99)00407-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have clarified for the first time how cyanidin 3-O-β-D-glucoside (C3G), which is a potent antioxidant anthocyanin, is absorbed and metabolized in vivo. Rats were orally administered C3G (0.9 mmol/kg body weight), and C3G rapidly appeared in the plasma. However, the aglycon of C3G (cyanidin; Cy) was not detected, although it was present in the jejunum. Protocatechuic acid (PC), which may be produced by degradation of Cy, was present in the plasma and the concentration was 8-fold higher than that of C3G. These results suggest that plasma PC and C3G may contribute to the antioxidant activity of the plasma. In the liver and kidney, C3G was metabolized to methylated C3G (methyl-C3G), suggesting that C3G and/or methyl-C3G act as antioxidants in the tissues.

【 授权许可】

Unknown